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High-Loaded Dosage Forms: Novel Platform Expands Spray-Dried Dispersion Utility
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"High-Loaded Dosage Forms: Novel Platform Expands Spray-Dried Dispersion Utility"
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Spray-dried amorphous solid dispersions (ASDs) show enormous promise in the delivery of drug compounds with low solubility. A novel platform expands the utility of this approach, enabling creation of ASD solid dosage forms with high drug loadings to meet patient needs.

The prevalence of active compounds with low aqueous solubility exceeds 70% in drug pipelines, preventing development of many compounds as effective medicines. Spray-dried amorphous solid dispersions (ASDs) are effective in increasing drug solubility and enhancing the bioavailability of such compounds, but the amount of excipients in ASDs may be too large to attain the high drug loadings needed for some therapies. Lonza has developed a novel platform that addresses this challenge, reducing tablet mass by nearly half and maintaining high drug loading, physical stability, and supersaturation. A case study is discussed which demonstrates how this platform can be used to prepare tablet formulations with high drug loadings, decreasing the size of tablets or the number of tablets that must be consumed by the patient for efficacy.


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