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"Mass Spectrometry-based Host Cell Protein Analysis in Biologics Development"
"Mass Spectrometry-based Host Cell Protein Analysis in Biologics Development"
Download this eBook and Learn the Advantages of LC-MS based HCP Profiling for Development of Complex Biologics.
Host cell proteins (HCPs) are impurities present in all therapeutics derived from biological sources, and as a critical quality attribute (CQA), they must be characterized in detail and controlled through the manufacturing process and in the final drug product. The individual protein contaminants that make up the HCP profile may vary significantly among individual biologic products including cell and gene therapies and expression systems, even for very closely related molecules. As such, the HCP profile must be analyzed to identify even low levels of potentially concerning species in a biologic drug. While ELISA methods have historically been the main approach to detecting total HCP content, LC-MS based HCP detection methods have increasingly become an expected orthogonal standard in successful biologic development. Download this eBook and learn the advantages of LC-MS based HCP profiling for development of complex biologics.
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